With Photoshop, you can resize an image without losing quality by using the "Image Size" dialog box. In the "Image Size" dialog box, you can change the width and height of the image. You can also change the resolution. The resolution is the number of pixels per inch.
How to reduce PDF file size in Photoshop without losing quality?
Go to “File.” From the drop-down menu next to “Format” (located below where you name the file), select “Photoshop PDF.” Click "Save." In the Options box, un-check the box next to Preserve Photoshop Editing Capabilities (this will significantly reduce your file size so that you can email it).