Howtosignalprocessing
- What are the advantages of multiple sequence alignment?
- What is the drawback of progressive multiple sequence alignment that uses a guiding tree?
- Why DNA sequence are less reliable for multiple sequence alignment?
- What is sequence alignment problem?
What are the advantages of multiple sequence alignment?
There is a unique advantage of multiple sequence alignment because it reveals more biological information than many pairwise alignments can. For example, it allows the identification of conserved sequence patterns and motifs in the whole sequence family, which are not obvious to detect by comparing only two sequences.
What is the drawback of progressive multiple sequence alignment that uses a guiding tree?
Progressive MSA is one of the fastest approaches, considerably faster than the adaptation of pair-wise alignments to multiple sequences, which can become a very slow process for more than a few sequences. One major disadvantage, however, is the reliance on a good alignment of the first two sequences.
Why DNA sequence are less reliable for multiple sequence alignment?
The small size of the DNA 'alphabet' makes alignment of nucleotide sequences inherently difficult: even a pair of completely unrelated DNA sequences will typically display ∼25% identity over their entire length and it is often possible to find extended local alignments where >50% of the aligned nucleotides are ...
What is sequence alignment problem?
The Sequence Alignment problem is one of the fundamental problems of Biological Sciences, aimed at finding the similarity of two amino-acid sequences. Comparing amino-acids is of prime importance to humans, since it gives vital information on evolution and development.
